Chromosomal Studies in Individuals with Infertility

Autores/as

  • Maria Elena de la Torre Santos Hospital Mariana Grajales. Villa Clara
  • Manuela Herrera Martínez Universidad de Ciencias Médicas Villa Clara
  • Ana Esther Algora Hernández Hospital Mariana Grajales. Villa Clara
  • Gisela Noche Gonzalez Hospital Mariana Grajales. Villa Clara
  • Arlan Machado Rojas Hospital Mariana Grajales. Villa Clara
  • Madeivy Paz Garcia Hospital Mariana Grajales. Villa Clara
  • Diley Rodríguez Conde Hospital Mariana Grajales. Villa Clara
  • Estrella Reyes Hernández Hospital Mariana Grajales. Villa Clara
  • Carolina Machado de la Torre Hospital Mariana Grajales. Villa Clara
  • Daniel González Benítez Hospital Mariana Grajales. Villa Clara

Palabras clave:

Infertility, Chromosomal Studies, karyotype

Resumen

Introduction: Infertile individuals frequently have chromosomal alteration. Objective: To determine the chromosomal constitution of infertile individuals.Methodology: A cross-sectional descriptive study was carried out based on the results of the karyotypes in peripheral blood in infertile individuals. The sample consisted of infertile patients of both sexes, from the province of Villa Clara who were studied in the Cytogenetics Laboratory of the Provincial Center of Genetics, between the years 1991 and 2017. We analyzed the chromosome formulas obtained and the age of the subjects at the time of diagnosis.Results: 232 individuals were studied, of which 97 were males and 135 females. 27.1% of the karyotypes were positive and in all, the sex chromosomes were involved. We found numerical chromosomal aberrations in thirty-one men (32%) in relation to Klinefelter Syndrome and variants. Thirty-two women (23.8%) had positive karyotype, where structural aberrations of the X chromosome and mosaicism predominated. The diagnosis of six women with karyotype 46, XY (Androgen insensitivity Syndrome) and two 45, X/46,XY (Mixed gonadal dysgenesis) was significant. The average age at diagnosis in men was 31 years and in women 22 years.Conclusions: Karyotyping is an essential study in infertility. The detailed clinical examination of this type of patients would facilitate early diagnosis and adequate therapeutics.

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Publicado

2020-01-28

Cómo citar

1.
de la Torre Santos ME, Herrera Martínez M, Algora Hernández AE, Noche Gonzalez G, Machado Rojas A, Paz Garcia M, et al. Chromosomal Studies in Individuals with Infertility. Rev Cubana Inv Bioméd [Internet]. 28 de enero de 2020 [citado 31 de agosto de 2025];38(5). Disponible en: https://revibiomedica.sld.cu/index.php/ibi/article/view/526