Emerging challenge of enzymatic production in antimicrobial resistance

Authors

  • Washington Paúl Culqui Molina
  • Fausto Sebastián Hurtado Garófalo
  • Rafael Alejandro López Haro

Keywords:

antimicrobial resistance, microorganisms, enzymes, antibiotics, resistance mechanisms

Abstract

Antimicrobial resistance represents a significant challenge to global public health, exacerbated by the inadequate use of antimicrobials and the rapid spread of resistant microorganisms. The objective of this study was to interpret, through a literature review, the emerging challenge of enzymatic production in antimicrobial resistance. Searches were conducted in databases such as PubMed, Scielo, Google Scholar, and Scopus, using specific terms in Spanish and English, and 29 articles published between January 2017 and July 2022 were included. The results highlight the prevalence of enzymes such as MRSA, MRSA, and ESBL in various microorganisms, conferring resistance to multiple classes of antibiotics. Resistance mechanisms such as the production of degrading enzymes, efflux pumps, and the transfer of resistance genes were identified. It is concluded that antimicrobial resistance is a complex problem that requires a multidisciplinary and sustained response in research and development of new treatments to ensure the continued effectiveness of antimicrobials.

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Published

2024-11-06

How to Cite

1.
Culqui Molina WP, Hurtado Garófalo FS, López Haro RA. Emerging challenge of enzymatic production in antimicrobial resistance. Rev Cubana Inv Bioméd [Internet]. 2024 Nov. 6 [cited 2025 Dec. 7];43. Available from: https://revibiomedica.sld.cu/index.php/ibi/article/view/3544