Oxidative stress in the pathophysiology of cardiovascular disease. New approaches of Aneurysmatic diseases. State of Art

Authors

  • Roger Rodríguez Guzmán Biomedical Sciences Department. Calixto García Faculty. University of Medical Sciences of Havana Anatomic Pathology Institute. Department of Biomedicine and Prevention. University of Rome Tor Vergata.
  • Maria Giovanna Scioli Anatomic Pathology Institute. Department of Biomedicine and Prevention. University of Rome Tor Vergata
  • Federico D’Amico Anatomic Pathology Institute. Department of Biomedicine and Prevention. University of Rome Tor Vergata
  • Ela María Céspedes Miranda Biomedical Sciences Department, Calixto García Faculty. University of Medical Sciences of Havana
  • Niurelkis Suárez Castillo Biomedical Sciences Department. Calixto García Faculty. University of Medical Sciences of Havana
  • Pilar Guzmán Díaz Familiar Medicine Department, Calixto García Faculty. University of Medical Sciences of Havana

Keywords:

Oxidative stress, cardiovascular disease, aneurysmatic diseases

Abstract

Introduction: Cardiovascular diseases are still the main cause of mortality all over the world.  Ischemic heart conditions are very well know, but aneurysmatic diseases. Endothelial damage seems to be the key in this illness. Objective. According to its importance, new risk factors and specifically biomarkers are needed. Methods: After looking for information in several databases such us: Medline- PubMed, Cochrane and Scielo, a review was done. Results: According literature, arterie’s conditions remain at the top ten cause of death of many countries such as Cuba were 2938 defunctions were registered during 2016. This condition importance is due to asymptomatic featuring so, when pain appears usually fatal complications just like dissection or rupture are presented. Through de major factors involved in this pathology aging, male sex, hypertension and left ventricular mass index ere described. Many biochemical parameters seem to be also coinvolved:  uric acid concentration, total reductive antioxidant capacity are some of them. Another proposed biomarkers are thioredoxin 1, peroxiredoxin 1 and iron. There is not still strong information about NOX4 or ROS, even though its role as a main actor in endothelial lesion through oxidative stress is very well known. Conclusion: Scientific community has realized about oxidative stress role according aneurysmatic diseases. Therefore, antioxidants could be an appropriate method for early diagnosis, follow-up evaluation and target therapy, but molecular studies are not still enough.

Downloads

Download data is not yet available.

Downloads

Published

2020-01-28

How to Cite

1.
Rodríguez Guzmán R, Giovanna Scioli M, D’Amico F, Céspedes Miranda EM, Suárez Castillo N, Guzmán Díaz P. Oxidative stress in the pathophysiology of cardiovascular disease. New approaches of Aneurysmatic diseases. State of Art. Rev Cubana Inv Bioméd [Internet]. 2020 Jan. 28 [cited 2025 Aug. 31];38(5). Available from: https://revibiomedica.sld.cu/index.php/ibi/article/view/522

Issue

Vol. 38 (2019): Suplemento Especial: II PanAmerican Congress of Physiological Sciences

Section

SHORT COMMUNICATIONS

License

Aquellos autores/as que tengan publicaciones con esta revista, aceptan los términos siguientes: Los autores/as conservarán sus derechos de autor y garantizarán a la revista el derecho de primera publicación de su obra, el cuál estará simultáneamente sujeto a la Licencia de reconocimiento de Creative Commons (CC-BY-NC 4.0) que permite a terceros compartir la obra siempre que se indique su autor y su primera publicación esta revista. Los autores/as podrán adoptar otros acuerdos de licencia no exclusiva de distribución de la versión de la obra publicada (p. ej.: depositarla en un archivo telemático institucional o publicarla en un volumen monográfico) siempre que se indique la publicación inicial en esta revista. Se permite y recomienda a los autores/as difundir su obra a través de Internet (p. ej.: en archivos telemáticos institucionales o en su página web) antes y durante el proceso de envío, lo cual puede producir intercambios interesantes y aumentar las citas de la obra publicada. (Véase El efecto del acceso abierto).

Como Revista Cubana de Investigaciones Biomédicas forma parte de la red SciELO, una vez los artículos sean aceptados para entrar al proceso editorial (revisión), estos pueden ser depositados por parte de los autores, si estan de acuerdo, en SciELO preprints, siendo actualizados por los autores al concluir el proceso de revisión y las pruebas de maquetación.