Invasive physiological study of coronary vasoreactivity and microcirculation

Authors

Keywords:

coronary microcirculation, coronary physiology, ischemic heart disease, coronary vasoreactivity.

Abstract

Noninvasive imaging is used to detect ischemic heart disease. Direct assessment of coronary microcirculatory responses to vasodilator stimuli and evaluation of vasomotor disturbances present advantages for interventional diagnostic procedures. The functional relevance of alterations in the coronary microcirculation and the endothelium-independent mechanisms of coronary microvascular dysfunction can be appreciated during the study of the coronary macrocirculation. Administration of vasoreactivity-inducing stimuli investigates endothelium-dependent mechanisms of microvascular coronary dysfunction and disorders of epicardial vasomotor tone. Interventional diagnostic procedures differentiate underlying endotypes in ischemic heart disease and guide a personalized therapy approach according to the patient's physiological response.

The study of coronary microcirculation can be estimated within the same procedure, and its diagnostic value serves to interpret the results of percutaneous coronary intervention. The present paper summarizes the current state of knowledge on the study of coronary microcirculation and its endothelium-independent mechanisms in coronary microvascular dysfunction. In addition, it presents the basic ideas for a correct interpretation of its results in the hemodynamics laboratory.

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Published

2024-09-08

How to Cite

1.
Alfonso Rodríguez E, Núñez Gil I, Mejía Rentería H. Invasive physiological study of coronary vasoreactivity and microcirculation. Rev Cubana Inv Bioméd [Internet]. 2024 Sep. 8 [cited 2025 Jul. 11];43. Available from: https://revibiomedica.sld.cu/index.php/ibi/article/view/2968

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