Internal tandem duplication of the tyrosine kinase 3 gene

Authors

Keywords:

PCR, FLT3, biomarker.

Abstract

Introduction: The polymerase chain reaction requires several procedures and controls to ensure the quality of the study. Quality control must be performed on the reverse transcript in order to determine the effectiveness of the process and move to the next step. It is checked with the amplification of a normal gene, which is interpreted by electrophoresis. Due to difficulties in importing reagents, it was proposed to replace this step with the identification of the tyrosine kinase 3 gene, which in acute myeloid leukemia can be affected by an internal tandem duplication type mutation.

Objective: To evaluate whether the biomarker internal tandem duplication of the tyrosine kinase 3 gene is useful as a control of the reverse transcription process within the polymerase chain reaction technique for molecular studies.

Methods: 235 bone marrow aspirate samples from hematological patients were analyzed in the molecular biology laboratory of the Institute of Hematology and Immunology between June 2017 and June 2019.

Results: 85.53 % presented only one band in capillary electrophoresis, corresponding to the wild-type allele, and in the rest, the normal band and the band corresponding to the mutated allele were observed. Thus, the presence of cDNA was verified in all samples.

Conclusions: The substitution of the control based on a normal gene, by the biomarker internal tandem duplication of the tyrosine kinase 3 gene, within the polymerase chain reaction technique, is possible and, moreover, useful as part of the laboratory protocol for the study of patients with oncohematological diseases.

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Author Biographies

Heidys Garrote Santana, Instituto de Hematología e Inmunología

Doctora en Ciencias Médicas. Especialista de 1er  Grado en Medicina General Integral Especialista de 1er y 2do Grado en Hematología Profesora Titular Investigadora Auxiliar

Ana María Amor Vigil, Instituto de Hematología e Inmunología

Doctora en Ciencias Farmacéuticas Licenciada en Química Investigadora Titular

Lesbia Fernández Martínez, Instituto de Hematología e Inmunología

Especialista de 1er Grado en Laboratorio Clínico Investigadora Agregada

Carmen Alina Díaz Alonso, Instituto de Hematología e Inmunología

Licenciada en Tecnología de la Salud Investigadora Agregada

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Published

2024-05-19

How to Cite

1.
Garrote Santana H, Amor Vigil AM, Fernández Martínez L, Díaz Alonso CA. Internal tandem duplication of the tyrosine kinase 3 gene. Rev Cubana Inv Bioméd [Internet]. 2024 May 19 [cited 2025 Nov. 6];43. Available from: https://revibiomedica.sld.cu/index.php/ibi/article/view/1884

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