Nanogels as prospective Biomaterial: Radio-induced Synthesis, Characterization, and Biological Assays

Authors

  • Adrian Alejandro Ges Naranjo Higher Institute of Technology and Applied Sciences, University of Havana
  • Herlys Viltres Cobas Centre of Research in Applied Science and Advanced Technology, Legaria-Unit National Polytechnic Institute
  • Liudy García Hernández Centre for Technological Applications and Nuclear Development
  • Liena Ponce Rey Faculty of Biology, University of Havana.
  • Yuri Aguilera Corrales Higher Institute of Technology and Applied Sciences, University of Havana
  • Isabelle Luz Laboratory of Biochemistry and Protein Chemistry, University of Brasilia
  • Katyelle Botelho Laboratory of Biochemistry and Protein Chemistry, University of Brasilia
  • Wagner Fontes Laboratory of Biochemistry and Protein Chemistry, University of Brasilia

Keywords:

biomaterial, cytotoxicity, gamma radiation, nanogel, neutrophil.

Abstract

Nowadays, there is a growing interest in biodegradable polymers-based materials due to their diverse application in the biomedical field. Most studied systems involve biocompatible micro and nanodevices, such as liposomes, dendrimer, micelles or polymeric nanogels. The use of Radiation Technology, specifically gamma radiation, to produce micro and nanogels raises the possibility to obtain higher purity products, an important feature for biomedical and pharmaceutical applications. The radio-induced synthesis, characterization, cytotoxicity evaluation, and immunological response of nanogels are described in this study. Nanogel synthesis was performed in the absence of oxygen using aqueous polyvinylpyrrolidone solutions. Crosslinking reactions were carried out at 25 °C in a gamma irradiation chamber with a 60Co source. Nanogels properties were analysed by Scanning Electron Microscopy, Attenuated Total Reflect

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Author Biographies

Adrian Alejandro Ges Naranjo, Higher Institute of Technology and Applied Sciences, University of Havana

Profesor e investigador

Departamento de Radioquímica

Herlys Viltres Cobas, Centre of Research in Applied Science and Advanced Technology, Legaria-Unit National Polytechnic Institute

Researcher

Liudy García Hernández, Centre for Technological Applications and Nuclear Development

Full Researcher

Liena Ponce Rey, Faculty of Biology, University of Havana.

Assistant professor

Department of Microbiology and Virology

Yuri Aguilera Corrales, Higher Institute of Technology and Applied Sciences, University of Havana

Full professor

Full researcher

Department of Radiochemistry

Isabelle Luz, Laboratory of Biochemistry and Protein Chemistry, University of Brasilia

Master student at University of Brasilia

Katyelle Botelho, Laboratory of Biochemistry and Protein Chemistry, University of Brasilia

Master student at University of Brasilia

Wagner Fontes, Laboratory of Biochemistry and Protein Chemistry, University of Brasilia

Full professor

University of Brasilia

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Published

2021-05-28

How to Cite

1.
Ges Naranjo AA, Viltres Cobas H, García Hernández L, Ponce Rey L, Aguilera Corrales Y, Luz I, et al. Nanogels as prospective Biomaterial: Radio-induced Synthesis, Characterization, and Biological Assays. Rev Cubana Inv Bioméd [Internet]. 2021 May 28 [cited 2025 Jul. 16];40(5). Available from: https://revibiomedica.sld.cu/index.php/ibi/article/view/1176