Effects of chronic supplementation of a hypercaloric diet on metabolic parameters and blood pressure in Wistar rats
Keywords:
Hypercaloric diet, blood pressure, metabolic parametersAbstract
Introduction: Obesity contributes to hypertension due to insulin resistance and hyperinsulinemia, increased adrenergic activity and aldosterone concentrations, sodium and water retention and increased cardiac output, alterations in endothelial function, through molecules such as leptin. and adiponectin and genetic factors. Insulin is capable of modifying physiological changes that can lead to both an increase and a decrease in blood pressure.
Objective: To evaluate the effects of chronic consumption of a high-fat and high-carbohydrate diet on systolic blood pressure (SBP) and metabolic parameters in Wistar rats.
Methods: Eight-week-old male Wistar rats were divided into 2 groups, control or non-obese rats consuming standard diet and obese rats supplemented with a high-fat, 20% (w/v) sucrose diet ad libitum for 48 weeks. At the end of the diet intervention, SBP, Lee's index, blood glucose and insulin were measured. Results: Obese rats had significantly lower systolic blood pressure than non-obese control rats. Obese rats also had significantly elevated serum insulin levels without significant changes in blood glucose levels.
Conclusions: Chronic supplementation with high-fat and high-carbohydrate diet induces obesity, hyperinsulinemia, insulin resistance and decreased blood pressure in Wistar rats.
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