Effect of Alzheimer's disease risk factors on P300 evoked potential
Keywords:
cognitive dysfunction, Alzheimer's disease, risk factors, P300 evoked potential.Abstract
Introduction: Evoked potentials have proven their sensitivity to early effects of Alzheimer's disease on cognitive functions.
Aim: To evaluate the effect of Alzheimer's disease risk factors on the P300 potential related to cognitive events.
Methods: An experimental case-control study was performed. The sample was non-probabilistic and consisted of 58 subjects at the authors' discretion. It was evaluated through the Minimental Test, and the P300 potential, related to cognitive events, was recorded in auditory modality. A multivariate analysis (Manova) was performed to determine the impact of risk factors on latency and amplitude.
Results: The level of cognitive functioning (p = 0.045), arterial hypertension (p = 0.003) and its association with hyperlipidemia (p = 0.023), schooling level (p = 0.04), overweight and obesity (p = 0.044) had an impact on P300 latency. Type 2 diabetes mellitus, although it had a significant effect on latency (p = 0.025), was not associated with its prolongation. Arterial hypertension plus hyperlipidemia (p = 0.011) and premenopausal oophorectomy (p = 0.044) significantly impacted amplitude.
Conclusions: The effect on cognitive impairment of arterial hypertension, arterial hypertension plus hyperlipidemia, overweight and obesity, premenopausal oophorectomy and low level of schooling can be demonstrated in the preclinical stage of Alzheimer's disease by P300 evoked potential. This confirms its advantages as an electrophysiological biomarker.
Downloads
References
1. Fruehwirt W, Dorffner G, Roberts S, Gerstgrasser M, Grossegger D, Schmidt R, et al. Associations of event-related brain potentials and Alzheimer’s disease severity: a longitudinal study. Prog Neuropsychopharmacol Biol Psychiatry. 2019;92:31-8. DOI: https://doi.org/10.1016/j.pnpbp.2018.12.013
2. Jadhav C, Kamble P, Mundewadi S, Jaiswal N, Mali S, Ranga S, et al. Clinical applications of EEG as an excellent tool for event related potentials in psychiatric and neurotic disorders. Int J Physiol Pathophysiol Pharmacol. 2022 [acceso 20/10/2024];14(2):73-83. Disponible en: https://pubmed.ncbi.nlm.nih.gov/35619664/
3. Olichney J, Xia J, Church KJ, Moebius HJ. Predictive power of cognitive biomarkers in neurodegenerative disease drug development: utility of the P300 event-related potential. Neural Plast. 2022;2022:2104880. DOI: https://doi.org/10.1155/2022/2104880
4. Gu L, Zhang Z. Exploring potential electrophysiological biomarkers in mild cognitive impairment: a systematic review and meta-analysis of event related potential studies. J Alzheimers Dis. 2017 [acceso 20/10/2024];58(4):1283-92. Disponible en: https://www.j-alz.com/content/exploring-potential-electrophysiological-biomarkers-mild-cognitive-impairment-systematic
5. Tarawneh HY, Mulders WHAM, Sohrabi HR, Martins RN, Jayakody DMP. investigating auditory electrophysiological measures of participants with mild cognitive impairment and alzheimer's disease: a systematic review and meta analysis of event-related potential studies. J Alzheimers Dis. 2021;84(1):419-48. DOI: https://doi.org/10.3233/JAD-210556
6. Montoya-Pedrón A, Ocaña-Montoya CM, Bolaño-Díaz GA. Potencial relacionado con eventos cognitivos P300 en el diagnóstico y clasificación del trastorno neurocognitivo debido a enfermedad de Alzheimer posible. Rev Neurol. 2020;71(1):11-8. DOI: https://doi.org/10.33588/rn.7101.2019341
7. Livingston G, Huntley J, Y Liu K, Costafreda S, Selbaek G, Alladi S, et al. Dementia prevention, intervention, and care: 2024 report of the Lancet standing Commission. Lancet. 2024;404:572-628. DOI: https://doi.org/10.1016/S0140-6736(24)01296-0
8. Esquivel JA, Montoya A. Factores de riesgo y biomarcadores de la enfermedad de Alzheimer. Rev Cub Med Milit. 2023 [acceso 20/10/2024];53(1). Disponible en: https://revmedmilitar.sld.cu/index.php/mil/article/view/16519
9. Folstein MF, Folstein SE, MCHugh PR. “Mini-mental state”. A practical method for grading the cognitive state of the patients for the clinician. J Psychiatr Res. 1975;12(3):189-98. DOI: https://doi.org/10.1016/0022-3956(75)90026-6
10. American Psychiatric Association. DSM-5. Manual diagnóstico y estadístico de los trastornos mentales. Buenos Aires: Editorial Médica Panamericana; 2016.
11. Gogisetti Y, Pathania M, Mittal S, Yadav P, Kharibam P, Kant R. Assessment of cognition in hypertensives and normotensives: a comparative P300 study. Cureus. 2022;14(8):e28397. DOI: https://doi.org/10.7759/cureus.28397
12. Krivonogova OV, Krivonogova EV, Poskotinova LV. A study of cognitive functions in elderly men from the Arctic region of the Russian Federation with arterial hypertension using the auditory event-related potentials P300. Ekol Chelov. 2024;31(2):162-71. DOI: https://doi.org/10.17816/humeco633767
13. Anandhalakshmi S, Rajkumar R, Arulmurugan K, Kumar J, Thirunavukarasu M. Study of neurocognitive function in type 2 diabetes mellitus patients using P300 event-related potential. Annals Neurosc. 2020;27(3-4):98-103. DOI: https://doi.org/10.1177/0972753120966824
14. Van der Westhuizen N, Biagio-de Jager L, Rheeder P. P300 event-related potentials in normal-hearing adults with type 2 diabetes mellitus. Am J Audiol. 2020;29:120-8. DOI: https://doi.org/10.1044/2019_AJA-19-00095
15. Braverman ER, Chen TJ, Chen AL, Kerner MM, Tung H, Waite RL, et al. Preliminary investigation of plasma levels of sex hormones and human growth factor(s), and P300 latency as correlates to cognitive decline as a function of gender. BMC Res Notes. 2009;2:126. DOI: https://doi.org/10.1186/1756-0500-2-126
16. Rocca W, Grossardt B, Shuster L. Oophorectomy, estrogen, and dementia: A 2014 update. Mol Cell Endocrinol. 2014;389(1-2):7-12. DOI: https://doi.org/10.1016/j.mce.2014.01.020
17. Hedges D, Janis R, Mickelson S, Keith C, Bennett D, Brown BL. P300 amplitude in Alzheimer's disease: a meta-analysis and meta-regression. Clin EEG Neurosci. 2016;47(1):48-55. DOI: https://doi.org/10.1177/1550059414550567
18. Begum T, Reza F, Ahmed I, Abdullah JM. Influence of education level on design-induced N170 and P300 components of event related potentials in the human brain. J Integr Neurosci. 2014;13(1):71-88. DOI: https://doi.org/10.1142/S0219635214500058
Downloads
Published
How to Cite
Issue
Section
License
Aquellos autores/as que tengan publicaciones con esta revista, aceptan los términos siguientes: Los autores/as conservarán sus derechos de autor y garantizarán a la revista el derecho de primera publicación de su obra, el cuál estará simultáneamente sujeto a la Licencia de reconocimiento de Creative Commons (CC-BY-NC 4.0) que permite a terceros compartir la obra siempre que se indique su autor y su primera publicación esta revista. Los autores/as podrán adoptar otros acuerdos de licencia no exclusiva de distribución de la versión de la obra publicada (p. ej.: depositarla en un archivo telemático institucional o publicarla en un volumen monográfico) siempre que se indique la publicación inicial en esta revista. Se permite y recomienda a los autores/as difundir su obra a través de Internet (p. ej.: en archivos telemáticos institucionales o en su página web) antes y durante el proceso de envío, lo cual puede producir intercambios interesantes y aumentar las citas de la obra publicada. (Véase El efecto del acceso abierto).
Como Revista Cubana de Investigaciones Biomédicas forma parte de la red SciELO, una vez los artículos sean aceptados para entrar al proceso editorial (revisión), estos pueden ser depositados por parte de los autores, si estan de acuerdo, en SciELO preprints, siendo actualizados por los autores al concluir el proceso de revisión y las pruebas de maquetación.
