Cardiac electrical and contractile properties of catechin

Authors

Keywords:

catechin, cardiovascular, flavonoids, cardiac contraction force, electrocardiogram, QTc, QRS, RR

Abstract

Introduction: Catechin is a flavonoid present in many vegetables consumed in the diet and has antioxidant and anti-inflammatory properties. There are few studies on the cardiovascular action and safety of catechin.
Objective: To evaluate the effects of catechin on the electrical and contractile activity of isolated and perfused hearts of Wistar rats.
Methods: The actions of catechin on the isolated and perfused hearts of rats were measured by the Langendorff method. The amplitude of the cardiac contraction force and the QT, QTc, QRS and RR intervals of the electrocardiogram were evaluated. The conditions (control and presence of catechin at different concentrations) were compared with a Student's t test for paired samples (p < 0.05), after checking the normality of the data.
Results: Catechin showed a tendency to prolong the QRS interval, but only significantly at the highest concentration studied (10 μmol/L). The QTc interval was not significantly affected by catechin. This flavonoid significantly prolonged the RR interval throughout the range of concentrations studied. Catechin showed a statistically significant negative inotrope in isolated hearts, in a manner dependent on the concentration of the flavonoid. The estimated concentration for 50% inhibition of cardiac contraction force was 5.36 ± 3.22 μmol/L.
Conclusions: Catechin showed direct cardiovascular actions with a good cardiovascular safety margin.

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Author Biography

Loipa Galán Martínez, Instituto de Cardiología y Cirugá Cardiovascular

Departamento de Docencia e Investigaciones

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Published

2025-06-09

How to Cite

1.
Galán Martínez L. Cardiac electrical and contractile properties of catechin. Rev Cubana Inv Bioméd [Internet]. 2025 Jun. 9 [cited 2025 Jul. 30];44. Available from: https://revibiomedica.sld.cu/index.php/ibi/article/view/3212

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Vol. 44 (2025): publicación continua

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ARTÍCULOS ORIGINALES

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