Lipid profile and redox state associated to the vaso-occlusive state in sickle cell anemia
Keywords:
Sickle cell anemia, oxidative stress, vaso-occlusive crisisAbstract
Introduction: Sickle cell disease is a highly prevalent hemoglobinopathy worldwide. Sickle cell hemolysis produces significant endothelial dysfunction by multiple mechanisms that include a significant state of oxidative stress and dyslipidemia accentuated in the vaso-occlusive crisis.
Objective: To characterize the asymptomatic and crisis states in sickle cell patients based on the evaluation of the redox state and the lipid profile.
Methods: From a cross-sectional analytical study, carried out at the Hematological Center of Santiago de Cuba, the asymptomatic states and vaso-occlusive crisis were compared using the contrast of means. The variables were related to the use of Pearson's correlation.
Results: A significant difference was observed in the evaluated groups regarding the concentrations of triacylglycerides (p = 0.003) and HDL-cholesterol (p = 0.009), as well as malonyldialdehyde as an indicator of oxidative damage to lipids (p = 0.001) and the glutathione (p = 0.001) and catalase (p = 0.005) expressing antioxidant response in patients. Similarly, triacylglycerides and cholesterol, LDL-cholesterol and cholesterol, LDL-cholesterol and triacylglycerides were positively related and, negatively, malonyldialdehyde and HDL-cholesterol, malonyldialdehyde and catalase, as well as malonyldialdehyde and glutathione.
Conclusions: During the vaso-occlusive crisis state, the marked oxidative damage to lipids and depression of antioxidant mechanisms reflected in this study is evident. The use of biomarkers evaluating redox status allowed a better characterization of them, contributing to the evaluation of patients, so they could be used as a tool during their follow-up.
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