Mesenchymal tumours of the head and neck: a 10-year institutional archival study

Authors

  • Shalini Krishnan Nitte (Deemed to be University), AB Shetty Memorial Institute of Dental Sciences (ABSMIDS), Mangalore, Karnataka-575018.
  • Varsha Salian Nitte (Deemed to be University), AB Shetty Memorial Institute of Dental Sciences (ABSMIDS), Mangalore, Karnataka-575018.
  • Neevan D'Souza Nitte (Deemed to be University), KS Hegde Medical Academy (KSHEMA), Mangalore, Karnataka-575018.
  • Pushparaja Shetty Nitte (Deemed to be University), AB Shetty Memorial Institute of Dental Sciences (ABSMIDS), Mangalore, Karnataka-575018.

Keywords:

biopsy, fibroma, oral cavity, oral pathology, osteosarcoma.

Abstract

Introduction:

Histopathological characterisation of benign and malignant lesions of the head and neck in a systematic and coherent way is an essential part of Oral Pathology and Oral Medicine.

Objective: To analyse and present the profile of the mesenchymal neoplasms in the head and neck including the oral cavity that have been reported in the institution in the past 10 years with emphasis on the histopathological types, frequency and location of the most common tumours.

Methodology:

A retrospective analysis was made of the 10-year records of reports of biopsy samples of patients maintained by the department of oral pathology showing histopathological diagnosis of connective tissue neoplasms. The data obtained was compiled for age, gender, site and histopathology of the lesions.

Results: Majority of the tumours were benign and patients were found to be in the 2nd or 4th decade of life with female preponderance. The most common benign tumour was fibroma where buccal mucosa was the commonest location and malignant tumour was osteosarcoma where mandible was the commonest site. While fibromas were seen among general adult population, osteosarcomas were more in the males (7.2%) and in the younger population (<20years). The uncommon tumours among benign variety were leiomyoma and teratoma while in malignant category 1 case of undifferentiated sarcoma was reported.

Conclusion: The findings in this study may be of help to oral and maxillofacial surgeons and general dentists in formulating diagnosis and rendering patient care in the existing local population.

Downloads

Download data is not yet available.

Author Biographies

Shalini Krishnan, Nitte (Deemed to be University), AB Shetty Memorial Institute of Dental Sciences (ABSMIDS), Mangalore, Karnataka-575018.

Professor, Department of Oral & Maxillofacial Surgery.

Varsha Salian, Nitte (Deemed to be University), AB Shetty Memorial Institute of Dental Sciences (ABSMIDS), Mangalore, Karnataka-575018.

Reader, Department of Oral & Maxillofacial Pathology.

Neevan D'Souza, Nitte (Deemed to be University), KS Hegde Medical Academy (KSHEMA), Mangalore, Karnataka-575018.

Msc, Pgdbm, Phd in Bio-Statistics, Associate Professor in Bio-statistics.

Pushparaja Shetty, Nitte (Deemed to be University), AB Shetty Memorial Institute of Dental Sciences (ABSMIDS), Mangalore, Karnataka-575018.

Professor and Head, Department of Oral & Maxillofacial Pathology.

References

1. Guedes MM, Albuquerque R, Monteiro M, Lopes CA, do Amaral JB, Pacheco JJ, et al. Oral soft tissue biopsies in Oporto, Portugal: an eight-year retrospective analysis. J Clin Exp Dent. 2015;7(5): e640-8. DOI: https://doi.org/10.4317/jced.52377

2. Masamatti SS, Gosavi AV. Benign soft tissue lesions of oral cavity: a histopathological study. J Clin Biomed Sci. 2016;6(3):88-90.

3. Barosa J, Ribeiro J, Afonso L, Fernandes J, Monteiro E. Head and neck sarcoma: analysis of 29 cases. Eur Ann Otorhinolaryngol Head Neck Dis. 2014;131(2):83-6. DOI: https://doi.org/10.1016/j.anorl.2012.11.007

4. Kalavrezos N, Sinha D. Head and neck sarcomas in adulthood: current trends and evolving management concepts. Br J Oral Maxillofac Surg. 2020;58(8):890-7. DOI: https://doi.org/10.1016/j.bjoms.2020.05.015

5. Al-Khateeb TH. Benign oral masses in a northern Jordanian population-a retrospective study. Open Dent J. 2009;3:147-53. DOI: http://doi.org/10.2174/1874210600903010147

6. Gonsalves WC, Chi AC, Neville BW. Common oral lesions: part II. Masses and neoplasia. Am Fam Physician. 2007 [access 24/11/2020];75(4):509-12. Available at: https://pubmed.ncbi.nlm.nih.gov/17323711/

7. Błochowiak K, Farynowska J, Sokalski J, Wyganowska-Świątkowska M, Witmanowski H. Benign tumours and tumour-like lesions in the oral cavity: a retrospective analysis. Post Derma i Alerg. 2019;36(6):744-51. DOI: https://doi.org/10.5114/ada.2018.78805

8. Naruse T, Yanamoto S, Yamada S, Rokutanda S, Kawakita A, Takahashi H, et al. Lipomas of the oral cavity: clinicopathological and immunohistochemical study of 24 cases and review of the literature. Indian J Otolaryngol Head Neck Surg. 2015;67 Supl 1:67-73. DOI: https://doi.org/10.1007/s12070-014-0765-8

9. Gundewar S, Kothari DS, Mokal NJ, Ghalme A. Osteomas of the craniofacial region: a case series and review of literature. Indian J Plast Surg. 2013;46(3):479-85. DOI: https://doi.org/10.4103/0970-0358.121982

10. Petur G, Rosenberg AE. Update on bone forming tumors of the head and neck. Head Neck Pathol. 2007;1:87-93. DOI: https://doi.org/10.1007/s12105-007-0023-4

11. Jones AC, Prihoda TJ, Kacher JE, Odingo NA, Freedman PD. Osteoblastoma of the maxilla and mandible: a report of 24 cases, review of the literature, and discussion of its relationship to osteoid osteoma of the jaws. Oral and maxillo pat. 2006;102(5):639-50. DOI: https://doi.org/10.1016/j.tripleo.2005.09.004

12. Jaffe HL. Benign osteoblastoma. Bull Hosp Joint Dis. 1956 [access 24/11/2020];17(2):141-51. Available at: https://pubmed.ncbi.nlm.nih.gov/13413389/

13. Lichtenstein L. Benign osteoblastoma; a category of osteoid-and bone-forming tumors other than classical osteoid osteoma, which may be mistaken for giant-cell tumor or osteogenic sarcoma. Cancer. 1956;9(5):1044-52. DOI: https://doi.org/10.1002/1097-0142(195609/10)9:5%3C1044::AID-CNCR2820090523%3E3.0.CO;2-O

14. Tröbs RB, Mader E, Friedrich T, Bennek J. Oral tumors and tumor-like lesions in infants and children. Pediatr Surg Int. 2003;19:639-45. DOI: https://doi.org/10.1007/s00383-003-0983-8

15. Mashhadi F, Moharamkhani V, Housh-mand B, Chaghazardi S, SepidehA. Prevalence of peripheral soft connective tissue lesions in patients referred to pathology department of Shahid Beheshti dental school, 1981-2006. J Mashhad Dent Sch. 2008 [access 24/11/2020];26(1):79-84. Available at: https://www.sid.ir/paper/22135/en

16. Neville BW, Damm DD, Allen CM, Bouquot JE. Oral and maxillofacial pathology. Philadelphia, EE.UU: WB Saunders; 2002. p. 574-8.

17. Regezi JA, Sciubba JJ. Oral pathology clinical pathologic correlations. Philadelphia, EE.UU: WB Saunders; 1999. p. 397-404.

18. Patel SG, Meyers P, Huvos AG, Wolden S, Singh B, Shaha AR, et al. Improved outcomes in patients with osteogenic sarcoma of the head and neck. Cancer. 2002; 95(7):1495-503. DOI: https://doi.org/10.1002/cncr.10849

19. Azizi T, Motamedi MHK, Jafari SM. Gnathic osteosarcomas: a 10-year multi-center demographic study. Indian J Cancer. 2009;46(3):231-3. DOI: https://doi.org/10.4103/0019-509X.52958

20. Nissanka EH, Amaratunge EA, Tilakaratne WM. Clinicopathological analysis of osteosarcoma of jaw bones. Oral Dis 2007;13(1):82-7. DOI: https://doi.org/10.1111/j.1601-0825.2006.01251.x

21. Olubemiga M, Folake O, Lanre W, Ladipo A, James O. Osteogenic sarcoma of the jaw bones: a single institution experience over a 21-year period. Oral and maxillo pat. 2006; 101(1):76-81. DOI: https://doi.org/10.1016/j.tripleo.2005.03.035

22. Jasnau S, Meyer U, Potratz J, Jundt G, Kevric M, Joos UK, et al. Craniofacial osteosarcoma. Experience of the cooperative German-Austrian-Swiss osteosarcoma study group. Oral Oncol 2008;44(3):286-94. DOI: https://doi.org/10.1016/j.oraloncology.2007.03.001

23. Baumhoer D, Brunner P, Eppenberger-Castori S, Smida J, Nathrath M, Jundt G. Osteosarcomas of the jaws differ from their peripheral counterparts and require a distinct treatment approach. Experiences from the DOESAK Registry. Oral Oncol. 2014;50(2):147-53. DOI: https://doi.org/10.1016/j.oraloncology.2013.10.017

24. El Kordy MA, El Baradie TS, El Sebai HI, Amin AAE, Khair SM. Osteosarcoma of the jaw: challenges in the diagnosis and treatment. J Egypt Natl Canc Inst. 2018; 30(1):7-11. DOI: https://doi.org/10.1016/j.jnci.2018.02.001

25. Etemad-Moghadam S, Tirgary F, Keshavarz S, Alaeddini M. Head and neck non-Hodgkin’s lymphoma: a 20-year demographic study of 381 cases. Int J Oral Maxillofac. Surg. 2010; 39(9):869-72. DOI: https://doi.org/10.1016/j.ijom.2010.03.029

26. Urquhart A, Berg R. Hodgkin’s and non-Hodgkin’s lymphoma of the head and neck. Laryngoscope. 2001;111(9):1565-9. DOI: https://doi.org/10.1097/00005537-200109000-00013

27. Pazoki A, Jansisyanont P, Ord RA. Primary non-Hodgkin’s lymphoma of the jaws: report of 4 cases and review of the literature. J. Oral Maxillofac. Surg. 2003;61(1):112-7. DOI: https://doi.org/10.1053/joms.2003.50018

28. Chittemsetti S, Guttikonda VR, Sravya T, Manchikatla PK. Solitary plasmacytoma of mandible: a rare entity. J Oral Maxillofac Pathol. 2019;23(1):136-9. DOI: https://doi.org/10.4103%2Fjomfp.JOMFP_175_18

29. Venkatesulu B, Mallick S, Giridhar P, Upadhyay AD, Rath GK. Pattern of care and impact of prognostic factors on the outcome of head and neck extramedullary plasmacytoma: a systematic review and individual patient data analysis of 315 cases. Eur. Arch. Oto-Rhino-L 2017;275;595-606. DOI: https://doi.org/10.1007/s00405-017-4817-z

30. Liu Y, Li K. Solitary plasmacytoma of maxillofacial bones: correlation of CT features with pathological findings. BIR. 2020;49(1):20190277. DOI: https://doi.org/10.1259/dmfr.20190277

31. Shaigany K, Fang CH, Patel TD, Park RC, Baredes S, Eloy JA. A population-based analysis of head and neck hemangiopericytoma. Laryngoscope. 2015;126(3):643-50. DOI: https://doi.org/10.1002/lary.25681

32. Rajendran A, Sivapathasundharam B. Shafer’s Textbook of Oral Pathology. New Delhi, India: Elsevier; 2009.

33. Wushou A, Miao XC, Shao ZM. Treatment outcome and prognostic factors of head and neck hemangiopericytoma: meta-analysis. Head Neck. 2015;37(11):1685-90. DOI: https://doi.org/10.1002/hed.23812

Downloads

Published

2023-01-27

How to Cite

1.
Krishnan S, Salian V, D’Souza N, Shetty P. Mesenchymal tumours of the head and neck: a 10-year institutional archival study. Rev Cubana Inv Bioméd [Internet]. 2023 Jan. 27 [cited 2025 Jul. 19];42(1). Available from: https://revibiomedica.sld.cu/index.php/ibi/article/view/1859

Issue

Vol. 42 (2023)

Section

ARTÍCULOS ORIGINALES

License

Aquellos autores/as que tengan publicaciones con esta revista, aceptan los términos siguientes: Los autores/as conservarán sus derechos de autor y garantizarán a la revista el derecho de primera publicación de su obra, el cuál estará simultáneamente sujeto a la Licencia de reconocimiento de Creative Commons (CC-BY-NC 4.0) que permite a terceros compartir la obra siempre que se indique su autor y su primera publicación esta revista. Los autores/as podrán adoptar otros acuerdos de licencia no exclusiva de distribución de la versión de la obra publicada (p. ej.: depositarla en un archivo telemático institucional o publicarla en un volumen monográfico) siempre que se indique la publicación inicial en esta revista. Se permite y recomienda a los autores/as difundir su obra a través de Internet (p. ej.: en archivos telemáticos institucionales o en su página web) antes y durante el proceso de envío, lo cual puede producir intercambios interesantes y aumentar las citas de la obra publicada. (Véase El efecto del acceso abierto).

Como Revista Cubana de Investigaciones Biomédicas forma parte de la red SciELO, una vez los artículos sean aceptados para entrar al proceso editorial (revisión), estos pueden ser depositados por parte de los autores, si estan de acuerdo, en SciELO preprints, siendo actualizados por los autores al concluir el proceso de revisión y las pruebas de maquetación.