Melatonin And Its Neuroimmunological Actions

Authors

  • Jorge Ramón Blanco-Carmona Pepe Portilla Provincial Pediatric Hospital. Pinar del Río. Cuba
  • William Quintero-Pérez Pepe Portilla Provincial Pediatric Hospital. Pinar del Río. Cuba
  • Alexander Ariel Padrón González Instituto de Ciencias Básicas y Preclínicas Victoria de Girón. Universidad de Ciencias Médicas de La Habana
  • Maricarmen González-Costa Instituto de Ciencias Básicas y Preclínicas Victoria de Girón. Universidad de Ciencias Médicas de La Habana
  • Meralys Iglesias Pepe Portilla Provincial Pediatric Hospital. Pinar del Río. Cuba

Keywords:

melatonin, inflammation, neurological diseases, immunological diseases

Abstract

Introduction:Melatonin is a neurohormone, synthesized mainly in the pineal gland, which regulates the circadian rhythm.

Objective: To describe the neuroimmunological actions produced by melatonin.

Matherials and methods: A review on the subject was carried out using articles of free access in the Pubmed database from 2015 to January 2019.

Discussion: The effects of melatonin on the wake-sleep cycle are known. Recently it has been shown that this neurohormone can modulate the immune response and reduce seizures in autoimmune and rheumatologic diseases. It induces the pattern of regulatory T lymphocytes and immunomodulatory cytokines maintaining the homeostasis of the internal environment. In the Central Nervous System inhibits the formation of free radicals, has antioxidant functions and can slow neurodegenerative processes. In the peripheral nerves decreases oxidative stress and cellular apoptosis. There are drugs that use melatonin as an active ingredient for its beneficial effects. In Cuba, only the history of a publication on this hormone is collected.

Conclusions: Melatonin can be a very useful element in the management of inflammatory and neurological diseases.

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Published

2019-05-27

How to Cite

1.
Blanco-Carmona JR, Quintero-Pérez W, Padrón González AA, González-Costa M, Iglesias M. Melatonin And Its Neuroimmunological Actions. Rev Cubana Inv Bioméd [Internet]. 2019 May 27 [cited 2025 Jul. 13];38(1). Available from: https://revibiomedica.sld.cu/index.php/ibi/article/view/157

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