Preliminary Monte Carlo simulation study of a 199Au radioactive nanoparticle in a simple cell model

Authors

Keywords:

dose distribution, dose profile, 199Au nanoparticle, cell model, PENELOPE.

Abstract

Introduction: Nanoparticles have diverse scientific and technological applications. Their use in tumor treatment is an open and continuously developing field of research.

Objectives: To model by Monte Carlo simulation a 199Au radioactive nanoparticle and to analyze its distribution in a simple cellular model.

Methods: A 199Au nanoparticle, 200 nm in diameter, was placed at the geometric center of the cell model. The PENELOPE v.2014 code was used to calculate and quantify the distribution and dose of beta minus (β-) and gamma (γ) particles emitted during the radioactive decay of the 199Au nanoparticle in the cell.

Results: The amount deposited by the β- particles resulted 100 times higher and with lower dispersion than that deposited by the γ particles. The simulation showed that the dose is completely deposited inside the cell and that the range of γ-radiation is larger.

Conclusions: PENELOPE v.2014 constitutes a suitable tool for single cell modeling with embedded 199Au nanoparticle; moreover, it allows obtaining the dose distributions and profiles generated by the particles emitted during decay. Due to the low toxicity and high degree of targeting of the 199Au nanoparticle, its applications in cancer therapy are considered promising.

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Author Biographies

Danny Giancarlo Apaza Veliz, Universidade de Sao Paulo

Magister en Física Aplicada a la Medicina y Biología, Licenciado en Física

Jorge Homero Wilches Visbal, Universidad del Magdalena, Facultad de Ciencias de la Salud

Doctor en Física Aplicada a la Medicina y Biología, Magíster en Física Médica, Ingeniero Físico

Patrícia Nicolucci, Universidade de Sao Paulo

Doctora y Magíster en Física Aplicada a la Medicina y Biología, Bachiller en Física

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Published

2023-08-21

How to Cite

1.
Apaza Veliz DG, Wilches Visbal JH, Nicolucci P. Preliminary Monte Carlo simulation study of a 199Au radioactive nanoparticle in a simple cell model. Rev Cubana Inv Bioméd [Internet]. 2023 Aug. 21 [cited 2025 Jul. 11];42(1). Available from: https://revibiomedica.sld.cu/index.php/ibi/article/view/1492

Issue

Vol. 42 (2023)

Section

ARTÍCULOS ORIGINALES

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