Efecto sinérgico de un bifosfonato con vitamina D

Autores/as

Palabras clave:

bifosfonatos, alendronato, colecalciferol, osteoporosis

Resumen

Introducción: Los bifosfonatos son considerados como un grupo de fármacos de gran utilidad en el tratamiento de enfermedades del tejido óseo ya que promueven su resorción. Han sido la primera línea para el tratamiento de la osteoporosis, enfermedad de Paget, mieloma múltiple e hipercalcemia maligna. Por su parte, la vitamina D es un nutriente esencial cuya función principal es la homeostasis de calcio (Ca+2) y fosfato (P43-).

Objetivo: Describir los aspectos moleculares y farmacológicos de la acción de un bifosfonato (alendronato sódico) y la vitamina D, por los cuales potencian mutuamente sus efectos en enfermedades óseas.

Métodos: Fueron seleccionadas las referencias más actualizadas que abordaran aspectos relevantes acerca del alendronato y la vitamina D. Se consultaron las bases de datos de PubMed, Uniprot y Protein Databank.

Conclusiones: El sinergismo entre alendronarto y vitamina D generan efectos benéficos en el tejido óseo. Sin embargo, existen efectos colaterales que pueden afectar a otros tejidos, por lo que su uso debe ser controlado.

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Biografía del autor/a

Jose Antonio Velazquez Dominguez, Instituto Politécnico Nacional, Escuela Nacional de Medicina y Homeopatía. Ciudad de México

Profesor de asignatura de la ENMH, Departamento de Ciencias Basicas Disciplinarias

Rubí Ixchell Morales Espíndola, Instituto Politécnico Nacional, Escuela Nacional de Medicina y Homeopatía. Ciudad de México

Estudiante del noveno semestre de la carrera de Medico Cirujano y Partero de la Escuela Nacional de Medicina y Homeopatia del Instituto Politecnico Nacional.

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Publicado

2021-01-28

Cómo citar

1.
Velazquez Dominguez JA, Morales Espíndola RI. Efecto sinérgico de un bifosfonato con vitamina D. Rev Cubana Inv Bioméd [Internet]. 28 de enero de 2021 [citado 15 de julio de 2025];40(1). Disponible en: https://revibiomedica.sld.cu/index.php/ibi/article/view/723

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