Hypothetical role of hypoxia-inducible factor-1 in adaptations to microgravity

Autores/as

  • Yang Sook Chun Seoul National University College of Medicine, Department of Physiology and Biomedical Sciences.
  • Alan R. Hargens University of California, Department of Orthopaedic Surgery.

Palabras clave:

microgravedad, vuelo espacial, factor inducible por hipoxia.

Resumen

Maintaining health in microgravity and overcoming environmental hazards such as cosmic radiation are essential for long-term space flight. Recent studies have focused on the involvement of hypoxia-inducible factor (HIF)-1 in altered gravity using cell-based or in vivo mouse model systems. HIF-1alpha and its target downstream gene expression are differentially expressed in hypergravity and microgravity. Nevertheless, underlying molecular mechanism of HIF-1alpha involvement is still unclear. Herein, we analyzed the 2019 Science paper by Garrett-Bakelman and coauthors in which NASA performed multidimensional analyses of long-term human spaceflight in identical twin astronauts. Correlations were found between the expression of HIF-1alpha related cytokines and prolonged space flight. We hypothesize that HIF-1alpha is a molecular target for the development of therapeutics to prevent the detrimental effects of microgravity and cosmic radiation on astronauts during long-term space flight.

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Publicado

2019-09-26

Cómo citar

1.
Sook Chun Y, Hargens AR. Hypothetical role of hypoxia-inducible factor-1 in adaptations to microgravity. Rev Cubana Inv Bioméd [Internet]. 26 de septiembre de 2019 [citado 31 de julio de 2025];38(3). Disponible en: https://revibiomedica.sld.cu/index.php/ibi/article/view/341

Número

Sección

COMUNICACIÓN BREVE