Neuroimmunological approach for evaluation of viral measles, mumps and rubella triple vaccine

Autores/as

Palabras clave:

neuroimmunology, triple vaccine, antibody index.

Resumen

Introduction: During the neuroinflammatory processes there are a poly-specific and polyclonal activation in the cerebrospinal fluid. It means that there can be quantified antibodies against all the components of the vaccines may have received.
Objective: To evaluate the immune response against measles, mumps and rubella in vaccinated pediatric patients.
Methods: All the serum and cerebrospinal fluid (CSF) paired samples from pediatric patients with neurological symptoms, that were submitted to hospitals from Havana City and were performed a lumbar puncture, were collected. Serum and CSF IgG, albumin were measured by immune-diffusion techniques using NOR and LC Partigen Immunoplates (Siemens, Marburg) and specific antibodies against measles, mumps and rubella were quantified by ELISA kits (Enzygnost, Siemens, Marburg). Reibergrams were employed in order to determine if there was IgG intrathecal synthesis. Later on, antibody index against the specific virus were calculated.
Results: In all the neuroimmune inflammation process were found antibody index against measles, mumps and rubella in a different ample confidence variation among the different virus. Antibodies against mumps are significantly different from the other ones. It could be due to a natural different immune response or due to a deficient vaccine quality lot. Also it was possible to identify six pediatric patients that had no immune antibody index at all. It coincides with a transient hypogammaglobulinemia of infancy in such patients.
Conclusions: This neuroimmunological approach can be used to evaluate the immune status in pediatric population.

Descargas

Los datos de descargas todavía no están disponibles.

Biografía del autor/a

Mileydis Cruz Quevedo, Instituto de Ciencias Básicas y Preclínicas «Victorias de Girón»

Médico residente de Inmunología en el Instituto de Ciencias Básicas y Preclínicas Victorias de Girón

Descargas

Publicado

2019-09-18

Cómo citar

1.
Castillo González W, Cruz Quevedo M, Rodríguez Pérez JA, Barrios Lamoth E, González Losada C, Dorta Contreras AJ. Neuroimmunological approach for evaluation of viral measles, mumps and rubella triple vaccine. Rev Cubana Inv Bioméd [Internet]. 18 de septiembre de 2019 [citado 13 de julio de 2025];38(3). Disponible en: https://revibiomedica.sld.cu/index.php/ibi/article/view/240

Número

Sección

COMUNICACIÓN BREVE